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Hongsheng Wu

  • Associate Teaching Professor
Academic Division: Mathematics, Analytics, Science, and Technology
781-239-4542
Dr. Hongsheng Wu received his M.S. in Math and Computer Science from Ohio University in 2001, his M.A. in Biostatistics from Boston University in 2005, and his Ph.D. in Biostatistics from Boston University in 2009.

Prior to joining Babson College, Dr. Wu taught at Wentworth Institute of Technology teaching computer science and data analytics in the School of Computing and Data Science.

Dr. Wu's research interests include clinical trials, health economics, genetics, and business analytics. He has been the lead statistician for large-scale multicenter trials such as a recently completed trial comparing two effective therapies to lower serum uric acid and therefore prevent further gout attacks. His research has been accepted for publication in peer-reviewed journals such as: New England Journal of Medicine, New England Journal of Medicine Evidence, JAMA Psychiatry, and Nature Communications.

Academic Degrees

  • Ph D, Boston University
  • MA, Boston University
  • MS, Ohio University

Courses

  • Degree Courses 2025

    • AQM 2000 PREDICTIVE BUSINESS ANALYTICS

  • Degree Courses 2024

    • QTM 6110 DATA EXPLORATION (QUANTITATIVE METHODS)
    • AQM 2000 PREDICTIVE BUSINESS ANALYTICS

Publications

Journal Articles

  • Lew, R., Wu, H. (in press). A Simple Way to Program Power Calculations. Citeseer.
  • Schechter, M., Anaya, N., Arteaga-Solis, E., Bagal, S., Morlando Geiger, J., McGarry, L., Oster, G., Van Brunt, K., Weycker, D., Wu, H. (in press). Impact of elexacaftor/tezacaftor/ivacaftor on healthcare resource utilization and costs among people with cystic fibrosis aged>= 12 years in the US: A retrospective analysis using commercial and Medicaid claims databases. Journal of Managed Care and Specialty Pharmacy. Page: S89--S89.
  • Helget, L.N., O'Dell, J.R., Newcomb, J.A., Androsenko, M., Brophy, M.T., Davis-Karim, A., England, B.R., Ferguson, R., Pillinger, M.H., Neogi, T., others, . (2023). Determinants of Achieving Serum Urate Goal with Treat-to-Target Urate-Lowering Therapy in Gout. Arthritis \& Rheumatology. Wiley Periodicals, Inc. Boston, USA.
  • Choi, S., Mo, E., Sima, C., Wu, H., Thakkar-Samtani, M., Tranby, E., Frantsve-Hawley, J., Barrow, JR, . (2023). Impact of COVID-19 on Dental Care Utilization and Oral Health Conditions in the United States. JDR Clinical \& Translational Research. Page: 23800844231165016. SAGE Publications Sage CA: Los Angeles, CA.
  • Schechter, M.S., Sabater-Anaya, N., Oster, G., Weycker, D., Wu, H., Arteaga-Solis, E., Bagal, S., McGarry, L.J., Van Brunt, K., Geiger, J.M. (2023). Impact of Elexacaftor/Tezacaftor/Ivacaftor on Healthcare Resource Utilization and Associated Costs Among People With Cystic Fibrosis in the US: A Retrospective Claims Analysis. Pulmonary Therapy. Page: 1--20. Springer Healthcare Cheshire.
  • O’Dell, J.R., Brophy, M.T., Pillinger, M.H., Neogi, T., Palevsky, P.M., Wu, H., Davis-Karim, A., Newcomb, J.A., Ferguson, R., Pittman, D., others, . (2022). Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management. NEJM evidence. Vol: 1, Issue: 3, Page: EVIDoa2100028. Massachusetts Medical Society.
  • Stolzmann, K., Lew, R.A., Miller, C.J., Kim, B., Wu, H., Bauer, M.S. (2022). Does balancing site characteristics result in balanced population characteristics in a cluster-randomized controlled trial?. Health Services and Outcomes Research Methodology. Page: 1--10. Springer.
  • Weisbord, S.D., Palevsky, P.M., Kaufman, J.S., Wu, H., Androsenko, M., Ferguson, R.E., Parikh, C.R., Bhatt, D.L., Gallagher, M. (2020). Contrast-associated acute kidney injury and serious adverse outcomes following angiography. Journal of the American College of Cardiology. Vol: 75, Issue: 11, Page: 1311--1320. American College of Cardiology Foundation Washington DC.
  • Weycker, D., Hanau, A., Hatfield, M., Wu, H., Sharma, A., Bensink, M.E., Chandler, D., Grossman, A., Tarantino, M. (2020). Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis. Journal of Medical Economics. Vol: 23, Issue: 2, Page: 184--192. Taylor \& Francis.
  • Lew, R.A., Miller, C.J., Kim, B., Wu, H., Stolzmann, K., Bauer, M.S. (2019). A method to reduce imbalance for site-level randomized stepped wedge implementation trial designs. Implementation Science. Vol: 14, Issue: 1, Page: 1--9. BioMed Central.
  • Boers, M., Singh, J.A., Cofield, S.S., Bridges, Jr, S.L., Moreland, L.W., O'Dell, J.R., Wu, H., Leatherman, S., Curtis, J.R. (2019). A novel method to combine assessment of benefit and harm: outcome measures in rheumatology 3$\times$ 3 methodology applied to two active comparator trials. Arthritis care \& research. Vol: 71, Issue: 2, Page: 319--322. Wiley Online Library.
  • Kraja, A.T., Liu, C., Fetterman, J.L., Graff, M., Have, C.T., Gu, C., Yanek, L.R., Feitosa, M.F., Arking, D.E., Chasman, D.I., others, . (2019). Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits. The American Journal of Human Genetics. Vol: 104, Issue: 1, Page: 112--138. Elsevier.
  • Timilsina, S., Brittan, K., O'Dell, J.R., Brophy, M., Davis-Karim, A., Henrie, A., Neogi, T., Newcomb, J., Palevsky, P., Pillinger, M., others, . (2018). Design and rationale for the veterans affairs “cooperative study program 594 comparative effectiveness in gout: allopurinol vs. febuxostat” trial. Contemporary Clinical Trials. Vol: 68, Page: 102--108. Elsevier.
  • Jovanova, O.S., Nedeljkovic, I., Spieler, D., Walker, R.M., Liu, C., Luciano, M., Bressler, J., Brody, J., Drake, A.J., Evans, K.L., others, . (2018). DNA methylation signatures of depressive symptoms in middle-aged and elderly persons: meta-analysis of multiethnic epigenome-wide studies. JAMA psychiatry. Vol: 75, Issue: 9, Page: 949--959. American Medical Association.
  • Yao, C., Chen, G., Song, C., Keefe, J., Mendelson, M., Huan, T., Sun, B.B., Laser, A., Maranville, J.C., Wu, H., others, . (2018). Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease. Nature communications. Vol: 9, Issue: 1, Page: 1--11. Nature Publishing Group.
  • Weycker, D., Grossman, A., Hanau, A., Wu, H., Hatfield, M., Sharma, A., Bensink, M.E., Chandler, D., Tarantino, M.D. (2018). Immune thrombocytopenia in US clinical practice: incidence and healthcare utilization/expenditures in the first 12 Months following diagnosis. Blood. Vol: 132, Page: 2239. Elsevier.
  • Weisbord, S.D., Gallagher, M., Jneid, H., Garcia, S., Cass, A., Thwin, S., Conner, T.A., Chertow, G.M., Bhatt, D.L., Shunk, K., others, . (2018). Outcomes after angiography with sodium bicarbonate and acetylcysteine. New England Journal of Medicine. Vol: 378, Issue: 7, Page: 603--614. Mass Medical Soc.
  • Garcia, S., Bhatt, D.L., Gallagher, M., Jneid, H., Kaufman, J., Palevsky, P.M., Wu, H., Weisbord, S.D., Group, P.T. (2018). Strategies to reduce acute kidney injury and improve clinical outcomes following percutaneous coronary intervention: a subgroup analysis of the PRESERVE trial. JACC: Cardiovascular Interventions. Vol: 11, Issue: 22, Page: 2254--2261. American College of Cardiology Foundation Washington, DC.
  • Yao, C., Chen, G., Song, C., Mendelson, M., Huan, T., Laser, A., Wu, H., Ho, J.E., Courchesne, P., Lyass, A., others, . (2017). Genome-wide association study of plasma proteins identifies putatively causal genes, proteins, and pathways for cardiovascular disease. bioRxiv. Page: 136523. Cold Spring Harbor Laboratory.
  • Weycker, D., Bensink, M., Wu, H., Doroff, R., Chandler, D. (2017). Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis based on real-world data from 2010 to 2015. Current Medical Research and Opinion. Vol: 33, Issue: 12, Page: 2115--2120. Taylor \& Francis.
  • Weycker, D., Li, X., Barron, R., Wu, H., Morrow, P.K., Xu, H., Reiner, M., Garcia, J., Mhatre, S., Lyman, G. (2015). Abstract P6-10-01: Risk of chemotherapy-induced febrile neutropenia (FN) in patients (pts) with non-metastatic breast cancer (BC) and documented risk factors for FN. Cancer Research. Vol: 75, Issue: 9\_Supplement, Page: P6--10. AACR.
  • Weycker, D., Li, X., Barron, R., Wu, H., Morrow, P., Xu, H., Reiner, M., Garcia, J., Mhatre, S.K., Lyman, G.H. (2015). Importance of risk factors for febrile neutropenia among patients receiving chemotherapy regimens not classified as high-risk in guidelines for myeloid growth factor use. Journal of the National Comprehensive Cancer Network. Vol: 13, Issue: 8, Page: 979--986. Harborside Press, LLC.
  • Weycker, D., Li, X., Barron, R., Wu, H., Morrow, P.K., Xu, H., Reiner, M., Garcia, J., Mhatre, S., Lyman, G.H. (2014). Incidence of Febrile Neutropenia Among Patients Receiving Chemotherapy Regimens Not Classified As High-Risk in Guidelines for Myeloid Growth Factor Use: Importance of “Risk Factor Stacking”. Blood. Vol: 124, Issue: 21, Page: 4824. Elsevier.
  • Edelsberg, J., Weycker, D., Barron, R., Li, X., Wu, H., Oster, G., Badre, S., Langeberg, W.J., Weber, D.J. (2014). Prevalence of antibiotic resistance in US hospitals. Diagnostic microbiology and infectious disease. Vol: 78, Issue: 3, Page: 255--262. Elsevier.
  • Weycker, D., Wu, H., Hagiwara, M., Li, X., Barron, R.L. (2014). Use of chemotherapy and same-day pegfilgrastim prophylaxis in US clinical practice. Blood. Vol: 124, Issue: 21, Page: 4825. Elsevier.
  • O'Seaghdha, C.M., Wu, H., Yang, Q., Kapur, K., Guessous, I., Zuber, A.M., K\"ottgen, Anna, ., Stoudmann, C., Teumer, A., Kutalik, Zolt\'an, ., others, . (2013). Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS genetics. Vol: 9, Issue: 9, Page: e1003796. Public Library of Science San Francisco, USA.
  • Werner, M., Russo, J., Wu, H., Rilett, D., Ahrabi, A., Grove, L., Dow, D., Valverde, P. (2013). The Current \& Future Vision Making Wentworth even better.
  • O'Seaghdha, C.M., Yang, Q., Wu, H., Hwang, S., Fox, C.S. (2012). Performance of a genetic risk score for CKD stage 3 in the general population. American journal of kidney diseases. Vol: 59, Issue: 1, Page: 19--24. Elsevier.
  • LeBlanc, M., Rilett, D., Russo, J., Werner, M., Wu, H. (2011). Introducing bioinformatics into the computer science curriculum: panel discussion. Journal of Computing Sciences in Colleges. Vol: 26, Issue: 6, Page: 130--132. Consortium for Computing Sciences in Colleges.
  • Yang, Q., Wu, H., Guo, C., Fox, C.S. (2010). Analyze multivariate phenotypes in genetic association studies by combining univariate association tests. Genetic epidemiology. Vol: 34, Issue: 5, Page: 444--454. Wiley Online Library.

Conference Proceedings

  • Helget, L., Davis-Karim, A., O'Dell, J., Mikuls, T., Newcomb, J., Androsenko, M., Brophy, M., England, B., Ferguson, R., Pillinger, M., others, . (2022). Efficacy and Safety of Allopurinol and Febuxostat in Patients with Gout and Chronic Kidney Disease: A Subgroup Analysis of the STOP Gout Study: ARTHRITIS \& RHEUMATOLOGY. Vol: 74, Page: 3616--3618.
  • Helget, L., O'Dell, J., Newcomb, J., Androsenko, M., Brophy, M., Davis-Karim, A., England, B., Ferguson, R., Pillinger, M., Neogi, T., others, . (2022). Health-Related Quality of Life Improvements Resulting from a Treat-to-Target Strategy in the Management of Gout: Post-Hoc Analysis of a Multicenter, Randomized, Double-Blind, Non-Inferiority Trial: ARTHRITIS \& RHEUMATOLOGY. Vol: 74, Page: 3553--3555.
  • Helget, L., O'Dell, J., Newcomb, J., Androsenko, M., Brophy, M., Davis-Karim, A., England, B., Ferguson, R., Pillinger, M., Neogi, T., others, . (2022). Race and Disease Severity Predict Reduced Response to Treat-to-Target Urate Lowering Therapy in Gout: Post-hoc Analysis of a Multicenter, Randomized, Double-Blind, Non-Inferiority Trial: ARTHRITIS \& RHEUMATOLOGY. Vol: 74, Page: 3129--3131.
  • Deligiannidis, L., Yu, C., Yun, M., Wu, H. (2019). Case Study: Skymap Data Analysis: Proceedings on the International Conference on Artificial Intelligence (ICAI). Page: 54--59.
  • Chen, K., Qin, S., Weycker, D., Wu, H., Vera-Llonch, M., Krasner, A., Remkus, L., Oster, G. (2017). Economic Burden of Chronic Hypoparathyroidism in US Clinical Practice: 99th Annual Meeting of the Endocrine Society.
  • Lew, R., Wu, H., Yu, C. (2017). Integrating Human Input for Decision Making with Informative Bayesian Beliefs: 2017 AAAI Spring Symposium Series.
  • Lew, R., Wu, H., Miller, C., Kim, B., Bauer, M.S. (2016). Balancing Site Characteristics for Stepped Wedge Designs.: 2016 Annual Research Meeting.
  • Weycker, D., Li, X., Barron, R., Wu, H., Morrow, P.K., Xu, H., Reiner, M., Garcia, J., Mhatre, S., Lyman, G. (2015). Risk of chemotherapy-induced febrile neutropenia (FN) in patients (pts) with non-metastatic breast cancer (BC) and documented risk factors for FN: CANCER RESEARCH. Vol: 75, Issue: 9.
  • Leatherman, S., Wu, H., Keystone, E., Brophy, M., O'Dell, J. (2014). Compliance in the Rheumatoid Arthritis Comparison of Active Therapies Trial: Triple Vs Etanercept: ARTHRITIS \& RHEUMATOLOGY. Vol: 66, Page: S1033--S1033.
  • Lew, R., Rybin, D., Hannagan, K., Wu, H., Keystone, E., Mikuls, T.R., O'Dell, J. (2014). Follow-up Data on the Rheumatoid Arthritis Comparison of Active Therapies Trial: Observational Cohort.: ARTHRITIS \& RHEUMATOLOGY. Vol: 66, Page: S670--S671.
  • Weycker, D., Chandler, D., Barron, R., Xu, H., Wu, H., Girardi, V., Edelsberg, J., Lyman, G.H. (2013). Risk of Infection Among Patients with Non-Metastatic Solid Tumors or Non-Hodgkin's Hodgkin's Lymphoma Receiving Myelosuppressive Chemotherapy and Antimicrobial Prophylaxis in US Clinical Practice: BLOOD. Vol: 122, Issue: 21.
  • Gagnon, D.R., Wu, H., Cho, K., Lawler, E.V. (2012). Obtaining Risk Ratios from Regression Models: A Cautionary Tale: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. Vol: 21, Page: 125--125.

Other

  • Wu, H. (2009). Methods for Genetic Association Studies Using Longitudinal and Multivariate Phenotypes in Families. Boston University.